Journal Club

Journal Club

Schedule *subject to change*

November 13, 2014- David B (Lit- practice talk)

November 20, 2014- Hannah (Data)

December 4, 2014- Eri (Lit) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

December 11, 2014 - David O (Data)

Past Journal Clubs

October 30, 2014

Hannah - Structural Basis for Protein Antiaggregation Activity of the Trigger Factor Chaperone Supplementary Materials

October 9, 2014

Shay - Protein Disulfide Isomerase Interacts with Tau Protein and Inhibits Its Fibrillization [1]

September 19, 2014

Abhi - Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan, SI

August 21, 2014

Eri - Systematic Analysis of Nucleation-Dependent Polymerization Reveals New Insights into the Mechanism of Amyloid Self-Assembly

Jul 31, 2014

Hannah - The Amino Terminus of Tau Inhibits Kinesin-Dependent Axonal Transport: Implications for Filament Toxicity

Tau oligomers and tau toxicity in neurodegenerative disease

Jul 10, 2014

Abhi - Metastability of Native Proteins and the Phenomenon of Amyloid Formation; SI

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules; SI

May 29, 2014

Hannah - Conformational Recognition of an Intrinsically Disordered Protein

May 15, 2014

Dennis - Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis

May 1, 2014

Ben - A single-molecule dissection of ligand binding to a protein with intrinsic dynamics

Apr 18, 2014

Eri - Remarkably Fast Coupled Folding and Binding of the Intrinsically Disordered Transactivation Domain of cMyb to CBP KIX; SI

Apr 3, 2014

Abhi - Full distance-resolved folding energy landscape of one single protein molecule

Mar 13, 2014

Eri - Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

Feb 27, 2014

David - Cooperative folding of tau peptide by coordination of group IIB metal cations during heparin-induced aggregation

Feb 13, 2014

Abhi - Charge interactions can dominate the dimensions of intrinsically disordered proteins

Feb 4, 2014

Eri - Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange

David - Comparative structural and conformational studies on H43R and W32F mutants of copper–zinc superoxide dismutase by molecular dynamics simulation

Abhi - A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis; SI